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Contraindicated (1)pentobarbital will lower the level or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or effect of ripretinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the extent or effect of fosaprepitant by influencing hepatic/intest